Table 5.
Univariate and multivariate COX regression analysis of factors associated with overall survival.
| Factors | Un-matched | Matched | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 0.428 | 0.520 | ||||||
| Female | 1 | 1 | ||||||
| Male | 1.268 (0.705-2.280) | 1.315 (0.571-3.031) | ||||||
| Age (y) | 0.001* | 0.054 | 0.102 | |||||
| ≤65 | 1 | 1 | 1 | |||||
| >65 | 2.435 (1.435-4.132) | 1.729 (0.991-3.015) | 1.858 (0.884-3.905) | |||||
| NRS 2002 score | <0.001* | 0.296 | 0.260 | |||||
| 1-2 | 1 | 1 | 1 | |||||
| 3-4 | 1.704 (0.997-2.912) | 1.100 (0.634-1.907) | 1.593 (0.741-3.428) | |||||
| 5-6 | 3.886 (1.978-7.635) | 1.773 (0.861-3.652) | 2.146 (0.730-6.312) | |||||
| ASA grade | 0.344 | 0.474 | ||||||
| 1-2 | 1 | 1 | ||||||
| 3-4 | 1.303 (0.753-2.252) | 1.312 (0.624-2.757) | ||||||
| Hypertension | 0.696 | 0.800 | ||||||
| No | 1 | 1 | ||||||
| Yes | 1.102 (0.677-1.794) | 1.096 (0.539-2.228) | ||||||
| Diabetes mellitus | 0.694 | 0.979 | ||||||
| No | 1 | 1 | ||||||
| Yes | 1.122 (0.633-1.988) | 1.011 (0.439-2.330) | ||||||
| Previous abdominal surgery | 0.521 | 0.883 | ||||||
| No | 1 | 1 | ||||||
| Yes | 1.245 (0.637-2.434) | 0.931 (0.359-2.411) | ||||||
| Tumor location | 0.002* | 0.144 | 0.012* | 0.012* | ||||
| Antrum | 1 | 1 | – | – | ||||
| Body | 0.946 (0.483-1.851) | 1.223 (0.509-2.055) | – | – | ||||
| Cardia | 1.652 (0.895-3.050) | 1.238 (0.639-2.399) | – | – | ||||
| Total | 4.850 (2.042-11.521) | 2.9245 (1.174-7.283) | – | – | ||||
| Differentiated degree | 0.534 | 0.895 | ||||||
| Differentiated | 1 | 1 | ||||||
| Undifferentiated | 1.350 (0.641-2.843) | 0.802 (0.240-2.675) | ||||||
| Signet ring carcinoma | 0.772 (0.367-1.623) | 1.110 (0.476-2.588) | ||||||
| Pathological type | 0.627 | 0.538 | ||||||
| Non-ulcerative type | 1 | 1 | ||||||
| Ulcerative type | 0.840 (0.417-1.694) | 0.638 (0.153-2.667) | ||||||
| TNM stage | <0.001* | <0.001* | 0.001* | 0.002* | ||||
| I | 1 | 1 | 1 | 1 | ||||
| II | 2.447 (1.026-5.834) | 1.897 (0.777-4.629) | 1.392 (0.374-5.186) | 1.333 (0.358-4.966) | ||||
| III | 6.332 (2.986-13.426) | 4.544 (2.077-9.944) | 4.939 (1.711-14.256) | 4.736 (1.636-13.705) | ||||
| Laparoscopic gastrectomy | 0.001* | 0.014* | 0.053 | |||||
| No | 1 | 1 | 1 | |||||
| Yes | 0.173 (0.063-0.474) | 0.270 (0.095-0.765) | 0.309 (0.094-1.014) | |||||
| B-I | 0.002* | 0.590 | 0.216 | |||||
| No | 1 | 1 | 1 | |||||
| Yes | 0.419 (0.239-0.733) | 0.840 (0.446-1.582) | 0.644 (0.320-1.294) | |||||
BMI, body mass index; ASA, American Society of Anesthesiologists; NRS 2002, nutritional risk screening 2002, TNM, tumor-node-metastasis.
*Statistically significant (P < 0.05).