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. 2023 Feb 13;13:1027254. doi: 10.3389/fonc.2023.1027254

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Copyright © 2023 Xie, Liu, Cai, Ye, Guo, Yang, Xiao, Tang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Preparation and mechanism of ADU-AAV-PD1@Gel. (A) Schematic illustration of the preparation of PVA-TSPBA hydrogel. (B) Flowchart of generation of the AAV-PD1 and formation of the ADU-AAV-PD1@Gel. (C) The ADU-AAV-PD1@Gel combined with RT treatment was performed in the GBM resection mice model. ADU-AAV-PD1@Gel was injected into the GBM resection cavity on day 11 after the GBM inoculation. The RT was performed on day 12, 13, and 14. (D) Mechanism of combining ADU-AAV-PD1@Gel with RT treatment for synergetic radioimmunotherapy of post-resection glioma (92).