TABLE 2.
Association analysis of two NOS1AP SNPs and QT interval in European-American and African-American Diabetes Heart Study participants free of myocardial infarction or QT-altering medication use
| SNP† | Alleles (major/minor) | Frequency of G allele | Genotypic means (QT interval in ms) | ß for additive genetic model | P value for additive genetic model* | ||
|---|---|---|---|---|---|---|---|
| All European Americans | |||||||
| rs10494366 | T/G | 0.35 | TT (n = 238) 386.4 ± 20.2 | TG (n = 266) 392.8 ± 19.1 | GG (n = 64) 395.7 ± 21.7 | 5.3 ± 1.3 | 5.7 × 10 −5 |
| rsl0918594 | C/G | 0.33 | CC (n = 254) 386.9 ± 19.1 | CG (n = 239) 393.9 ± 20.1 | GG (n = 58) 399.4 ± 21.2 | 6.4 ± 1.3 | 1.5 × l0 −6 |
| Diabetic European Americans only | |||||||
| rs10494366 | T/G | 0.35 | TT (n = 203) 385.2 ± 20.9 | TG (n = 214) 391.8 ± 19.2 | GG (n = 54) 396.5 ± 22.2 | 5.9 ± 1.4 | 5.1 × 10 −5 |
| rsl0918594 | C/G | 0.33 | CC (n = 213) 385.7 ± 19.5 | CG (n = 195) 392.9 ± 20.1 | GG (n = 47) 399.6 ± 22.7 | 7.1 ± 1.5 | 1.6 × l0 −6 |
| All African Americans | |||||||
| rs10494366 | G/T | 0.54 | TT (n = 22) 386.1 ± 20.6 | TG (n = 51) 385.1 ± 18.2 | GG (n = 40) 391.5 ± 23.4 | 3.2 ± 2.7 | 0.24 |
| rsl0918594 | G/C | 0.55 | CC (n = 36) 387.7 ± 17.8 | CG (n = 36) 385.1 ± 18.6 | GG (n = 41) 395.7 ± 23.4 | 4.1 ± 2.4 | 0.08 |
| Diabetic African Americans only | |||||||
| rs10494366 | G/T | 0.54 | TT (n = 19) 383.3 ± 20.4 | TG (n = 50) 382.1 ± 17.7 | GG (n = 34) 390.7 ± 24.8 | 4.4 ± 2.9 | 0.14 |
| rsl0918594 | G/C | 0.55 | CC (n = 32) 385. 8 ± 17 8 | CG (n = 33) 382. 7 ± 18 4 | GG (n = 38) 395. 8 ± 23 4 | 5.2 ± 2.5 | 0.04 |
*
P values reported are for the additive genetic model for association with QT interval adjusted for RR interval, age, sex, diabetes affection status (where appropriate), and BMI. P values shown in bold represent significance at the P < 0.05 level.
†
Chromosome 1 physical positions: 160352309 (rs10494366) and 160297312 (rs10918594) relative to National Center for Biotechnology Information dbSNP build 126.