TABLE 2.
Results of the in-person outpatient clinic visit according to Nijmegen score
| Nijmegen score ≤22 | Nijmegen score >22 | p-value | |
| Patients n | 140 | 37 | |
| mMRC (0–4) (n=177) | <0.001 | ||
| 0 | 82 (58.6) | 5 (13.5) | |
| 1–2 | 51 (36.4) | 25 (67.6) | |
| 3–4 | 7 (5) | 7 (18.9) | |
| Cough (n=172) | 12 (8.8) | 11 (30.6) | <0.01 |
| Lung CT scan (n=171) | <0.01 | ||
| Normal lung CT scan | 42 (31.1) | 21 (58.3) | |
| Persistent ground-glass opacities | 62 (45.9) | 13 (37.1) | |
| Lung fibrotic lesions | 31 (23) | 2 (5.7) | |
| Pulmonary function tests (n=157) | |||
| FEV1 % pred | 91.4±18.6 | 88.7±14.8 | 0.37 |
| FVC % pred | 89.7±16.4 | 87.0±16.5 | 0.40 |
| FEV1/FVC | 82.1±7.7 | 82.2±6.5 | 0.96 |
| TLC % pred | 82.4±15.7 | 84.2±13.5 | 0.51 |
| DLCO % pred | 86.7±22.7 | 88±20.5 | 0.70 |
| Obstructive pattern | 5 (4.1) | 1 (2.9) | 0.84 |
| Restrictive pattern | 55 (47.4) | 12 (36.4) | 0.26 |
| DLCO <70% pred | 27 (22.7) | 6 (18.2) | 0.93 |
| 6MWT distance m | 474 (395–516) | 404 (338–472) | <0.01 |
| Psychological and neurological assessment | |||
| Cognitive complaint (n=159) | 55 (43.7) | 24 (72.7) | <0.01 |
| Cognitive impairment (n=159) | 48 (38.1) | 13 (39.4) | 1.00 |
| Symptoms of anxiety (HADS-A) (n=169) | 32 (23.9) | 21 (61.8) | <0.001 |
| Symptoms of depression (BDI-13) (n=170) | 20 (14.7) | 14 (43.8) | <0.01 |
| Insomnia (ISI) (n=168) | 64 (47.8) | 26 (76.5) | <0.01 |
| Symptoms of PTSD (PCL-5) (n=169) | 12 (8.9) | 12 (35.3) | <0.01 |
| 36-item Short-form Health Survey (n=130) | |||
| Physical functioning | 80 (55–90) | 50 (35–65) | <0.001 |
| Role physical | 50 (25–100) | 25 (0–25) | <0.01 |
| Mental health | 66.7 (33.3–100) | 33.3 (0–66.7) | <0.01 |
| Vitality | 56.2 (37.5–75) | 31.2 (25–37.5) | <0.001 |
| Role emotional | 80 (65–90) | 55 (40–55) | <0.001 |
| Social functioning | 75 (50–100) | 50 (37.5–62.5) | <0.001 |
| Bodily pain | 83 (66.5–100) | 29 (16.5–58) | <0.001 |
| General health | 60 (45–80) | 35 (25–60) | <0.001 |
Data are presented as n (%), mean±sd or median (IQR) unless otherwise stated. Cognitive complaint was defined as an impaired McNair score, reported cognitive symptoms or both. Cognitive impairment was defined as an impairment of either the MoCA or d2-R score. Symptoms of anxiety are defined as a HADS-A score >7. Symptoms of depression were defined as a BDI-13 test score >7. Insomnia was defined as an ISI >7, and PTSD was defined as a PCL-5 score >30 (supplementary table 1). The European Community for Coal and Steel (ECCS) reference values were used for lung volume and TLC was expressed without adjustment for ethnicity. mMRC: modified Medical Research Council; CT: computed tomography; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLC: total lung capacity; DLCO: diffusing capacity of the lung for carbon monoxide; 6MWT: 6-min walk test; HADS-A: Hospital Anxiety and Depression Scale; BDI-13: Beck Depression Inventory-13 items; ISI: Insomnia Severity Index; PTSD: post-traumatic stress disorder; PCL-5: Post-traumatic Stress Disorder Checklist for DSM-5.