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. 2023 Feb 16;8(2):218–223. doi: 10.1016/j.ncrna.2023.02.005

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — The role of miRNAs in the regulation of mitochondrial biogenesis. ↑: up-regulation; ↓: down-regulation; PGC-1α: peroxisome proliferator-activated receptor coactivator-1α; ERR-α: estrogen receptor-related receptor α; P38MAPK: mitogen-activated protein kinase; NRF1: nuclear respiratory factor 1; TFAM: mitochondrial transcription factor A. PARP-2: poly ADP-ribose polymerase-2; IR or T2DM can resulted in up-regulation of miR-106b expression and down-regulation of miR-149 expression, thereby inhibiting the expression of its target genes ERR-α and PARP-2. IR/T2DM also can up-regulate the expression of miR-761 and miR-23a, and down-regulate the expression of miR-133a, which leads to down-regulation of its target gene PGC-1α.