Table 1.

Expansion of Prevotellaceae replaces other bacterial families. The 20 most abundant families were compared with Prevotellaceae using linear regression. Listed are the slope, Pearson coefficient, and p value. Also included is the mean relative abundance between the saline and morphine groups with a p-value. Only Ruminococcaceae and Clostridales_vadinBB60_group were statistically different between the saline and morphine groups

Taxonomic Groups			Relative Abundance (Means)			Correlations with Prevotellaceae
Phylum	Order	Family	Slope	Morphine	P Value	Slope	R Squared	r	P Value
Firmicute	Clostridales	Ruminococcaceae	19.38	9.58	0.0317	−0.357 ± 0.04615	0.8821	−0.9392	< 0.0001
Bacteroidete	Bacteroidales	Rikenellaceae	5.52	3.85	0.3095	−0.1147 ± 0.01253	0.9128	−0.9554	< 0.0001
Spirochaete	Spirochaetia	Spirochaetaceae	1.92	1.86	0.4206	−0.06702 ± 0.02473	0.4786	−0.6918	0.0267
Bacteroidete		p-2534–18B5_gut_group	2.09	1.33	0.3095	−0.09722 ± 0.03222	0.5323	−0.7296	0.0166
Firmicute		Firmicutes_Unclassified	1.29	0.53	0.0556	−0.02817 ± 0.005146	0.7893	−0.8884	0.0006
Bacteroidete	Bacteroidales	Bacteroidales_RF16_group	0.88	0.48	0.2063	−0.02298 ± 0.008787	0.4609	−0.6789	0.0309
Proteobacteria	Campylobacterales	Helicobacteraceae	0.12	0.23	0.2222	0.005076 ± 0.001536	0.5771	0.7597	0.0108
Bacteroidete	Bacteroidales	Paludibacteraceae	1.23	0.38	0.2857	−0.04528 ± 0.01665	0.4803	−0.693	0.0263
Firmicute	Clostridales	Clostridales_vadinBB60_group	0.63	0.15	0.0317	−0.01877 ± 0.006339	0.5229	−0.7231	0.0181