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Receiver operating characteristic curves of prediction models for COPD occurring early in life (age < 50) with predictive variables of 1) PRS, 2) early-life risk factors, and 3) PRS and early-life risk factors in COPDGene non-Hispanic white (A) and African American (B) participants. Models with PRS were adjusted for principal components of genetic ancestry. AUC: area under curve, PRS: polygenic risk score.
