Table 1.
Sample characteristics by status of COPD diagnosis at baseline visit. COPDGene participants with previously diagnosed COPD reported a physician diagnosis of COPD prior to the baseline visit.
| COPDGene NHW participants | COPDGene AA participants | FHS participants | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Previously diagnosed (n=2115) |
Newly diagnosed (n=696) |
No COPD* (n=3836) |
Previously diagnosed (n=444) |
Newly diagnosed (n=309) |
No COPD* (n=1711) |
COPD* (n=491) | No COPD* (n=6321) | |||
| Polygenic risk score | 0.22 (1.34) | 0.22 (1.32) | −0.17 (1.30) | 0.18 (1.30) | 0.27 (1.37) | −0.10 (1.33) | 0.66 (1.34) | −0.08 (1.31) | ||
| Age at baseline visit | 65.8 (11.6) | 62.8 (12.8) | 60.0 (13.7) | 60.6 (12.1) | 55.4 (10.9) | 51.9 (7.8) | 57.0 (17.0) | 46.0 (16.0) | ||
| Sex (male) | 1176 (55.6%) | 388 (55.7%) | 1913 (49.9%) | 228 (51.4%) | 184 (59.5%) | 1008 (58.9%) | 257 (52.3%) | 2940 (46.5%) | ||
| Smoking status (ever-smokers)** | 100% | 100% | 100% | 100% | 100% | 100% | 384 (78.2%) | 3240 (51.3%) | ||
| Pack-years of smoking | 51.3 (34.5) | 45.0 (28.1) | 37.0 (25.0) | 38.3 (26.2) | 37.3 (26.4) | 33.3 (21.3) | 35.5 (32.1) | 12 (21.5) | ||
| Age at smoking initiation | 16.0 (4.0) | 16.0 (4.0) | 16.0 (4.0) | 16.0 (4.0) | 16.0 (5.0) | 16.0 (5.0) | 18.0 (3.0) | 17.0 (3.0) | ||
| Baseline FEV1 % predicted | 44.3 (27.1) | 66.4 (18.9) | 90.5 (18.3) | 44.5 (27.2) | 63.4 (21.5) | 96.0 (17.2) | 69.9 (15.1) | 98.5 (16.1) | ||
Continuous variables were shown as medians (interquartile ranges). Categorical variables were shown as numbers (percentages). NHW: non-Hispanic white; AA: African American, FHS: Framingham Heart Study; FEV1: forced expiratory volume in 1s.
*
COPD: GOLD spirometry grades 2-4
**
All COPDGene participants had a smoking history of 10 pack-years or greater