Table 4.

Mutations associated with hospitalized cases due to COVID-19.

	Frequency	Crude OR (95% CI)	p-value	Adjusted OR (95% CI)†	p-value
N:R203K Non-hospitalized Hospitalized	3406 (87.7%) 473 (12.2%)	1.00 0.53 (0.42,0.66)	< 0.001	1.00 0.61 (0.47,0.79)	< 0.001
ORF1a:T3255I Non-hospitalized Hospitalized	3731 (88.3%) 467 (11.1%)	1.00 0.58 (0.44,0.76)	< 0.001	1.00 0.61 (0.45,0.83)	< 0.001
ORF3a:G49V Non-hospitalized Hospitalized	402 (95.0%) 21 (5.0%)	1.00 0.36 (0.23,0.57)	< 0.001	1.00 0.40 (0.25,0.64)	< 0.001
S:D950N Non-hospitalized Hospitalized	33 (87.6%) 469 (12.4%)	1.00 1.52 (1.17,1.97)	< 0.001	1.00 1.41 (1.01,1.95)	0.03
S:G142D Non-hospitalized Hospitalized	569 (93.3%) 41 (6.7%)	1.00 0.50 (0.36,0.70)	< 0.001	1.00 0.42 (0.29,0.61)	< 0.001
S:L452R Non-hospitalized Hospitalized	3254 (87.5%) 465 (12.5%)	1.00 1.54 (1.20,1.99)	< 0.001	1.00 1.49 (1.08,2.07)	0.01
S:T478K Non-hospitalized Hospitalized	3901 (88.0%) 530 (12.0%)	1.00 2.17 (1.17,4.02)	0.01	1.00 2.54 (1.21,5.35)	0.01
S:T95I Non-hospitalized Hospitalized	2803 (89.6%) 326 (10.4%)	1.00 0.68 (0.57,0.82)	< 0.001	1.00 0.71 (0.57,0.87)	< 0.001

CI, confidence interval; NA, not applicable; OR, odds ratio.

†Odds ratios adjusted for age and sex.