Table 1.

Baseline demographics of included patients

Variable	Intervention group (N = 240) Frequency (%)	Control group (N = 480) Frequency (%)	p-value
Age
< 70 years	123 (51.25)	257 (53.54)
≥ 70 years	117 (48.75)	223 (46.46)	0.56
Gender
Male	95 (39.58)	208 (43.33)	0.33
Female	145 (60.42)	272 (56.67)
Health Plan
Low-income subsidy	118 (49.17)	236 (49.17)
No-subsidy	122 (50.83)	244 (50.83)	1.00
Prescriber specialty
General	207 (86.25)	410 (88.36)
Specialty	27 (11.25)	54 (11.64)	0.96
Missing	6 (2.50)	16 (3.33)
Myocardial infarction
Yes	4 (1.67)	10 (2.08)
No	236 (98.33)	470 (97.92)	0.70
Depression
Yes	31 (12.92)	56 (11.67)
No	209 (87.08)	424 (88.33)	0.62
Congestive heart failure
Yes	26 (10.83)	30 (6.25)
No	214 (89.17)	450 (93.75)	0.03
Stroke
Yes	10 (4.17)	18 (3.75)
No	230 (95.83)	462 (96.25)	0.78
Coronary artery disease
Yes	63 (26.25)	92 (19.17)
No	177 (73.75)	388 (80.83)	0.03
Refill type
< 90 days	26 (10.83)	55 (11.46)
≥ 90 days	214 (89.17)	425 (88.54)	0.80
Number of other medications on index date
≤ 2	169 (70.42)	340 (70.8.)
> 2	71 (29.58)	140 (29.17)	0.90
Previous hospitalizations
≥ 1	26 (10.83)	45 (9.38)
None	214 (89.17)	435 (90.63)	0.53
Prevalent users
No	25 (10.42)	90 (18.75)	0.004
Yes	215 (89.58)	390 (81.25)
Baseline trajectories
Gaps in adherence	102 (42.50)	177 (25.21)
Gradual decline	94 (39.17)	182 (37.92)	0.09
Rapid decline	44 (18.33)	121 (25.21)
Regimen complexity, mean (SD)	4.27 (4.32)	3.86 (3.94)	0.20
CMS risk score, mean (SD)	1.50 (0.99)	1.36 (0.83)	0.04

CMS Centers for Medicare and Medicaid Services, SD standard deviation