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. 2023 Feb 7;66(4):2566–2588. doi: 10.1021/acs.jmedchem.2c01434

Table 1. SAR Exploration of the Leads 11 and 12.

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a

Physicochemical properties were determined using Discovery Studio version 2021.

b

IC50 values and inhibition ratio of EGFRWT and EGFRL858R/T790M were calculated using the in-house Kinase-Glo assay, and the IC50 values represent the mean of at least two independent experiments and are within ±15%.