Table 1. SAR Exploration of the Leads 11 and 12.
Physicochemical properties were determined using Discovery Studio version 2021.
IC50 values and inhibition ratio of EGFRWT and EGFRL858R/T790M were calculated using the in-house Kinase-Glo assay, and the IC50 values represent the mean of at least two independent experiments and are within ±15%.