Table 3. SAR Exploration of 15 and 29 by the Introduction of Solubilizing Groups in Phenyl Ring B.

^aPhysicochemical properties were determined using Discovery Studio version 2021.

^bThe IC₅₀ values and inhibition ratio of EGFR^WT and EGFR^L858R/T790M were calculated using the in-house Kinase-Glo assay, and the IC₅₀ values represent the mean of at least two independent experiments and are within ±15%.

^cThe CC₅₀ values represent the mean of at least two independent experiments and are within ±15%.