Table 2. In Vitro Inhibition of HSET and Ligand Efficiencies of 13 and 19–32.

^aInhibition of recombinant full-length HSET with preformed microtubules and 3 μM ATP measured in ADP-Glo format, mean (±SD) for n ≥ 3 atoms.

^bLigand efficacy was calculated using LE = −1.4Log(IC₅₀ [M])/number of non-hydrogen atoms.

^cLipophilic ligand efficacy was determined using the equation LLE = −Log(IC₅₀ [M]) – cLogP, where cLogP was calculated using MoKa from Molecular Discovery.

^dFrom a single determination.