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. 2023 Feb 2;66(4):2832–2850. doi: 10.1021/acs.jmedchem.2c01884

Table 4. SAR Exploration of the Northern Parta.

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a

IC50 and Ki values are geometric means of multiple independent measurements (n ≥ 3 for enzymatic and cellular hHSD17B13, n = 2 for enzymatic mHSD17B13). nd = not determined. *Real IC50 value unclear due to limits of the assay wall; Ki values (NAD+) should be used for comparison.