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. 2023 Feb 14;66(4):2330–2346. doi: 10.1021/acs.jmedchem.2c01572

Table 2. Glutamate Analogues Inhibitors of the Excitatory Amino Acid Transporter 2.

  Ki (μM)
 Ratio
  
Compound EAAT1 EAAT2 EAAT3 Ratio EAAT2 vs EAAT1 Ratio EAAT2 vs EAAT3 Ref
32 >3000 59 ± 18 >3000 >100 >100 (157)
33 >3000 23 ± 6 >3000 >100 >100 (157)
34 79 ± 7 8 ± 2 61 ± 14 9.9 7.6 (157)
40 1000–3000 95 3000 10.5–31.6 31.6 (181)