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. 2023 Feb 8;164(4):bqad021. doi: 10.1210/endocr/bqad021

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Effect of ROSI, LG100268, 2,4-DTBP, and 2,6-DTBP on lipid accumulation and adipogenic marker gene expression in human MSCs. Cells were treated with 500 nM ROSI, 100 nM LG100268, or different concentrations of 2,4-DTBP or 2,6-DTBP as indicated. Three replicate wells were included for each group in a 24-well plate for lipid accumulation assays or in 12-well plates for adipogenic marker gene expression assay. (A) effects of chemical exposure on adipogenesis in hMSCs. Data are expressed as lipid accumulation normalized to cellular DNA content. (B-E) effects of chemical exposure on expression of adipogenic markers in hMSCs. Data are expressed as fold induction over vehicle control. Error bars represent the standard error of the mean for 3 replicates. *P ≤ .05, **P ≤ .01, ***P ≤ .001 compared with cells treated with 0.1% DMSO vehicle control.