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. 2023 Feb 24;30:10732748231159706. doi: 10.1177/10732748231159706

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — The CD47-SIRPα signal axis. The interaction between CD47 and SIRPα recruits SHP-1/2, leading to the phosphorylation of two tyrosine residues of ITIMs in the intracellular structural domain of SIRPα. Phosphorylation of SHP-1/2 prevents the accumulation of myosin-IIA, which forms phagocytic synapses, resulting in sending a “don’t eat me” signal. Blocking the CD47-SIRPa axis could restore phagocytosis. Abbreviations: SHP-1, Src homology 2 containing tyrosine phosphatase 1; SHP-2, Src homology 2 containing tyrosine phosphatase 2; ITIMs, immunoreceptor tyrosine inhibitory motifs.