NMN treatment reduced the neurological damage and improved neurological function after TBI. A and B) Nissl staining at 8 days after TBI in the Brain sections (n = 3 per group). C) Brain water content of damaged hemisphere 1day post-TBI (n = 3 per group). D) mNSS score at 1, 3, 5, and 7 days following TBI/sham (n = 6 per group). E) Escape latency in MWM test 3 to 7 days following TBI/sham (n = 5 sham group, n=6 TBI and TBI + NMN group). F) Escape latency at test day following TBI/sham (*p < 0.05, **p < 0.01, and ***p < 0.001 TBI vs Sham group; #p < 0.05 and ##p < 0.01 TBI vs TBI +NMN group).