Table 1.
Regulation of MUC5B expression in airway epithelial cells.
| Species | Effector | Pathway | Transcriptional factors | Secretion | References |
|---|---|---|---|---|---|
| Bacteria spp | LPS/staphylococcus enterotoxin | MAPKs | CREB/AP1/SP1/ NF-κB | + | (129-137) |
| Cytokines | IL-1 β | NF-κB | + | (132, 138, 139) | |
| IL-17A | NF-κB | + | (132, 139, 140) | ||
| IL-6 | MAPKs | CREB/AP1/SP1/ NF-κB | + | (131-135, 140, 141) | |
| STAT3 | FOX | Decrease | (119, 142, 143) | ||
| IL-13 | STAT6 | FOXA2 | Decrease | (119, 144, 145) | |
| Lipid Mediator | PGD2 | MAPKs | CREB/AP1/SP1/ NF-κB | + | (119, 131-135, 146) |
| Oxidation factors | ROS | MAPKs | NF-κB | + | (147) |
Note: Different stimuli in airway epithelial cells can regulate MUC5B expression, including certain bacterial components, some interleukins, oxidative factors, lipid mediators, which may induce MUC5B overexpression through MAPK, STAT3, or STAT6 pathways. Some important transcription factors are also directly or indirectly involved in MUC5B overexpression.