Table 3.
Linear mixed models results on cognitive measures for HS and MCI/AD groups stratified by APOE
| HC | MCI/AD | |||
|---|---|---|---|---|
| APOE E3/E3 N= 106 |
APOE E4 Carriers N= 45 |
APOE E3/E3 N= 70 |
APOE E4 Carriers N= 138 |
|
| MMSE | BDNF (F1,102= 0.00/p= 1.00) TIME (F3,291= 0.18/p= 0.99) BDNF×TIME(F3,291=1.37/p=0.99) |
BDNF (F1,41= 0.24/p= 0.86) TIME (F3,119= 0.46/p= 0.87) BDNF×TIME(F3,119=0.05/p=0.98) |
BDNF (F1,66= 0.20/p=0.77) TIME (F3,155= 19.74/p<0.001) BDNF×TIME(F3,155=0.42/p=0.77) |
BDNF (F1,134= 1.92/p= 0.30) TIME (F3,315= 45.68/ p<0.0001) BDNF×TIME(F3,315=0.94/p=0.55) |
| Logical Memory Immediate | BDNF (F1,102= 2.61/p= 0.65) TIME (F3,291= 5.45/ p=0.04) BDNF×TIME(F3,291= 0.43/p=0.99) |
BDNF (F1,41= 1.38/p=0.63) TIME (F3,119= 2.28/p=0.50) BDNF×TIME(F3,119=1.15/p=0.63) |
BDNF (F1,66= 3.81/p=0.15) TIME (F3,154=6.59/p=0.001) BDNF×TIME(F3,154=0.65/p=0.77) |
BDNF (F1,134= 5.63/p=0.05)
TIME (F3,313= 19.16/ p<0.0001) BDNF×TIME(F3,313=0.10/p=0.96) |
| ADAS Memory | BDNF (F1,102= 0.47/p= 0.99) TIME (F3,289= 0.57/p= 0.99) BDNF×TIME(F3,289= 1.28/p=0.99) |
BDNF (F1,41= 0.03/p= 0.90) TIME (F3,119= 2.64/p= 0.40) BDNF×TIME(F3,119=1.82/p=0.63) |
BDNF (F1,66= 0.37/p= 0.77) TIME (F3,152= 16.78/ p<0.001) BDNF×TIME(F3,152=0.37/p=0.77) |
BDNF (F1,134= 5.72/p= 0.05)
TIME (F3,313= 28.45/ p<0.0001) BDNF×TIME(F3,313=0.67/p=0.71) |
| Logical Memory Delayed | BDNF (F1,102= 3.50/p= 0.48) TIME (F3,290= 0.81/p= 0.99) BDNF×TIME(F3,290= 0.24/p=0.99) |
BDNF (F1,41= 2.32/p= 0.63) TIME (F3,119= 0.77/p= 0.77) BDNF×TIME(F3,119=1.53/p=0.63) |
BDNF (F1,66= 2.35/p= 0.28) TIME (F3,154= 5.95/ p<0.01) BDNF×TIME(F3,154=1.87/p=0.28) |
BDNF (F1,134= 3.27/p= 0.15) TIME (F3,312= 7.74/ p<0.0001) BDNF×TIME(F3,312=1.64/p=0.30) |
| ADAS No Memory | BDNF (F1,102= 0.09/p= 0.99) TIME (F3,286= 0.98/p= 0.99) BDNF×TIME(F3,286= 1.06/p=0.99) |
BDNF (F1,41= 0.95/p= 0.63) TIME (F3,117= 2.72/p= 0.40) BDNF×TIME(F3,117=0.45/p=0.87) |
BDNF (F1,66= 0.53/p= 0.77) TIME (F3,149= 21.20/ p<0.001) BDNF×TIME(F3,149=1.04/p=0.67) |
BDNF (F1,134= 0.99/p= 0.46) TIME (F3,306= 30.63/ p<0.0001) BDNF×TIME(F3,306=0.11/p=0.96) |
| Digit Span | BDNF (F1,102= 0.02/p= 0.99) TIME (F3,291= 0.50/p= 0.99) BDNF×TIME(F3,291=0.40/p= 0.99) |
BDNF (F1,41= 0.13/p= 0.87) TIME (F3,119= 1.13/p= 0.63) BDNF×TIME(F3,119=0.91/p=0.74) |
BDNF (F1,66= 0.13/p= 0.77) TIME (F3,152= 12.37/p<0.001) BDNF×TIME(F3,152=2.25/p=0.21) |
BDNF (F1,134= 4.95/p= 0.06)
TIME (F3,310= 15.43/ p<0.0001) BDNF×TIME(F3,310=0.17/p=0.96) |
| Digit-Symbol | BDNF (F1,102= 0.11/p= 0.99) TIME (F3,288= 2.99/p= 0.32) BDNF×TIME(F3,288= 0.05/p=0.99) |
BDNF (F1,41= 0.60/p= 0.74) TIME (F3,119= 1.26/p= 0.63) BDNF×TIME(F3,119=0.38/p=0.88) |
BDNF (F1,66= 0.15/p= 0.77) TIME (F3,148= 14.63/p<0.001) BDNF×TIME(F3,148=0.73/p=0.77) |
BDNF (F1,134= 1.02/p= 0.46) TIME (F3,308= 20.45/ p<0.0001) BDNF×TIME(F3,308=0.34/p=0.89) |
| Semantic Fluency | BDNF (F1,102= 0.54/p= 0.99) TIME (F3,291= 0.71/p= 0.99) BDNF×TIME(F3,291=1.16/p= 0.99) |
BDNF (F1,41= 1.19/p= 0.63) TIME (F3,119= 0.84/p= 0.75) BDNF×TIME(F3,119=0.24/p=0.90) |
BDNF (F1,66= 0.14/p= 0.77) TIME (F3,154= 9.06/ p<0.001) BDNF×TIME(F3,154=0.38/p=0.77) |
BDNF (F1,134= 5.53/p= 0.05)
TIME (F3,311= 38.99/ p<0.0001) BDNF×TIME(F3,311=2.00/p=0.21) |
| Trail A | BDNF (F1,102= 0.00/p= 0.99) TIME (F3,290= 3.72/p= 0.18) BDNF×TIME(F3,290= 0.22/p=0.99) |
BDNF (F1,41= 0.17/p= 0.87) TIME (F3,119= 3.76/p= 0.19) BDNF×TIME(F3,119=0.26/p=0.90) |
BDNF (F1,66= 1.06/p= 0.58) TIME (F3,148= 7.60/ p<0.001) BDNF×TIME(F3,148=1.70/p=0.34) |
BDNF (F1,134= 0.65/p= 0.55) TIME (F3,308= 15.55/ p<0.0001) BDNF×TIME(F3,308=0.34/p=0.89) |
| Trail B | BDNF (F1,102= 0.19/p= 0.99) TIME (F3,290= 1.59/p= 0.95) BDNF×TIME(F3,290=0.51/p= 0.99) |
BDNF (F1,41= 1.31/p= 0.63) TIME (F3,117= 6.33/p= 0.01) BDNF×TIME(F3,117=1.36/p=0.63) |
BDNF (F1,66= 0.13/p= 0.77) TIME (F3,132= 7.72/ p<0.001) BDNF×TIME(F3,132=0.46/p=0.77) |
BDNF (F1,134= 1.28/p= 0.41) TIME (F3,274= 16.12/ p<0.0001) BDNF×TIME(F3,274=0.52/p=0.80) |
*
BDNF significant and trend effects are in bold (p<0.10); All p values have been FDR corrected