Fig. 5.

Prediction performance of prediction models using all six omics combinations for hold-out set validation. Each classifier is applied to predict the asthma status of children at year 3 using all six omics combinations (in total 63). The missing values of miRNA, mRNA and metabolomics data were imputed using the median values. The heatmap plot shows the performance of each prediction method in 32 balanced subjects with 16 healthy controls and 16 asthmatic cases. 1: GWAS; 2: miRNA; 3: mRNA; 4: Microbiome; 5: Metabolomics; 6: DNA methylation