Table 2.
Multifunctional nano-formulations used in TACE therapy of HCC
| Nano-formulations | Materials | Applications | Drugs | Refs. |
|---|---|---|---|---|
| Gold nanospheres | HAuNS, lipiodol | Drug-carrier; PTT; embolic agent | DOX | [63] |
| Nano-clusters | pMNCs, lipiodol | Drug-carrier; embolic agent; MRI | DOX | [73] |
| Nanocomposites | α-Fe2O3 nanocubes, PDA, and lipiodol | Drug-carrier; PTT; embolic agent; MRI | DOX | [74] |
| UiO-66/Bi2S3 NPs | Drug-carrier; PTT; embolic agent | DOX | [75] | |
| BSA, CuS NPs | Drug-carrier; PTT; embolic agent; MRI | DOX | [76] | |
| Microspheres complex | Carrageenan, inhexol and SPION | Biocompatibility, Drug-carrier; embolic agent; imaging (MRI and X-ray) | DOX | [53] |
| Gelatin and Fe3O4 NPs | Drug-carrier; PTT; embolic agent; MRI | ADR | [60] | |
| Alginate and USPIO NPs | Biocompatibility; Drug-carrier; embolic agent; MRI | AMO | [52] | |
| Calcium alginate and tantalum NPs | Drug-carrier; embolic agent; X-ray imaging real-time | DOX | [62] | |
| USPIO nanocluster and alginate | Drug-carrier; embolic agent; MRI | MEAN | [77] | |
| PDA, SPION | Drug-carrier; PTT; embolic agent; MRI | DOX | [54] | |
| Microbubble complex | Albumin NPs and Lipiodol | Drug-carrier; drug release triggered by ultrasound; real-time monitoring | DOX | [78] |
| Hybrid composites | PVA and iron oxide nanoshell | Drug-carrier; embolic agent; MRI | DOX | [55] |
HAuNS hollow gold nanoshells, pMNCs porous magnetic nano-clusters, PDA polydopamine, CuS copper sulfide, SPION superparamagnetic iron oxide nanoparticles, USPIO ultrasmall superparamagnetic iron oxide, MEAN 6-methoxyethylamino numonafide, PVA poly vinyl alcohol, ADR Adriamycin, AMO amonafide