TABLE 1.
Frequency of ipsilateral eye defects among all NBDPS-eligible cataract cases (N = 592), National Birth Defects Prevention Study, 2000–2011
| Unilateral cataractsa |
Bilateral cataractsa |
||||
|---|---|---|---|---|---|
| All cases (n = 592) |
Total (n = 362) |
Isolatedb (n =
341) |
Total (n = 228) |
Isolatedb (n =
189) |
|
| Ipsilateral eye defects | n (%) | n (%) | n (%) | n (%) | n (%) |
| Persistent fetal vasculature | 73 (12.3) | 67 (18.5) | 66 (19.4) | 5 (2.2) | 4 (2.1) |
| Microphthalmia | 57 (9.6) | 35 (9.7) | 28 (8.2) | 21 (9.2) | 13 (6.9) |
| Glaucoma | 22 (3.7) | 7 (1.9) | 6 (1.8) | 15 (6.6) | 10 (5.3) |
| Coloboma | 16 (2.7) | 12 (3.3) | 11 (3.2) | 3 (1.3) | 1 (0.5) |
| Anterior segment dysgenesis | 15 (2.5) | 8 (2.2) | 5 (1.5) | 7 (3.1) | 4 (2.1) |
| Microcornea | 14 (2.4) | 5 (1.4) | 4 (1.2) | 9 (4.0) | 5 (2.7) |
| Corneal opacity | 13 (2.2) | 6 (1.7) | 3 (0.9) | 7 (3.1) | 4 (2.1) |
| Optic nerve defects | 13 (2.2) | 6 (1.7) | 4 (1.2) | 7 (3.1) | 3 (1.6) |
| Vitreoretinopathy | 10 (1.7) | 5 (1.4) | 4 (1.2) | 5 (2.2) | 4 (2.1) |
| Lens defects | 9 (1.5) | 7 (1.9) | 7 (2.1) | 2 (0.9) | 2 (1.1) |
| Retinal detachment | 7 (1.2) | 5 (1.4) | 5 (1.5) | 2 (0.9) | 1 (0.5) |
| Aniridia | 4 (0.7) | 2 (0.6) | 2 (0.6) | 2 (0.9) | 2 (1.1) |
| Nasolacrimal duct obstruction | 3 (0.5) | 2 (0.6) | 2 (0.6) | 1 (0.4) | 1 (0.5) |
| Other eye defectsc | 9 (1.5) | 4 (1.1) | 3 (0.9) | 5 (2.2) | 2 (1.1) |
a
Two cases with unknown laterality excluded.
b
Includes all isolated cases, with and without ipsilateral eye defects.
c
Includes birth defects of the orbit, eyelids, cornea, and iris.