Figure 5.

Representative imaging changes seen with immune checkpoint inhibitor–induced hypophysitis. (A) Representative changes in the MRI appearance in a subset of 6 subjects within this cohort relative to CPI initiation and hypophysitis diagnosis. The clinical course in the subject highlighted in (B) is outlined by the dashed line. (B) Serial coronal T1 post-contrast MRIs demonstrate a normal appearing pituitary gland and infundibulum (i), followed by an enlarged pituitary gland and thickened infundibulum (ii), and ultimately a partially empty sella (iii).