Table 5.

Assessment of reported exercise variables of frequency, intensity, time, and type (FITT) in a manner that would permit intervention replication and determination if intervention met public health physical activity guidelines.⁴⁴

Trial	Exercise Study Arm(s)	Frequency	Intensity	Time	Type	Total FITT Criteria Reported	Meet Current PA Guidelines (AEx|REx)
Randomized controlled trials of exercise as a monotherapy (Table 1)
Doyne et al., 198738	AEx					3
	REx					2
Singh et al., 199720	PREx					4
Blumenthal et al., 199950	AEx					4
Dunn et al., 200521	AEx PHD-3d					2
	AEx PHD-5d					2
	AEx LD-3d					2
	AEx LD-5d					2
Singh et al., 200522	HI-PREx					4
	LO-REx					4
Blumenthal et al., 200723	AEx					4
Krogh et al., 201251	AEx					4
Randomized controlled trials of exercise as an adjunct to psychotherapy for major depression (Table 2)
Jacquart et al., 201452	Psych-Walk					2
Oertel-Knochel et al., 201453	AEx					4
Kerling et al., 201554	AEx					4
Randomized controlled trials of exercise as an adjunct to pharmacotherapy for major depression (exercise combined with pharmacotherapy as a treatment arm or all subjects on stable dose of pharmacotherapy) (Table 3)
Blumenthal et al., 199950	AEx					4
Pilu et al., 200755	PA					2
Mota-Pereira al., 201156	AEx					4
Danielsson et al., 201457	PA					3
Belvederi Murri et al., 201558	P-AEx					4
	NP-AEx					4
Carneiro et al., 201559	AEx					3
Legrand & Neff, 201660	AEx					4
Salehi et al., 201661	AEx					4
Siqueira et al., 201662	AEx					2
Gujral et al., 201963	AEx					4
Moraes et al., 202064	PREx					4
	NP-AEx					4
Randomized controlled trials of exercise as an adjunct to standard care for major depression (Table 4)
Martinsen et al., 198565	AEx					3
Veale et al., 199266 Study 1	AEx					2
Veale et al., 199266 Study 2	AEx					2
Knubben et al., 200767	AEx					4
Krogh et al., 200968	P-AEx					4
	PREx					4
Doose et al., 201569	AEx					4
Hallgren et al., 201570	Ex					2
Schuch et al., 201571	AEx					2
Helgadóttir et al., 201672	Ex-Light					3
	Ex-Mod					3
	Ex-Vig					3
Olson et al., 201773	AEx					4
Buschert et al., 201974	AEx					2
Chau et al., 202075	Ex		AEx			3-AEx 2-REx	AEx
			REx				REx
Haussleiter et al., 202076	Ex					2
La Rocque et al., 202177	AEx					2
Clinical trials examining the relationship of molecular mechanisms and clinical outcomes (Table 6)
Krogh et al., 2010161	P-AEx					4
	PREx					4
Toups et al., 2011162	AEx					0
Krogh et al., 2012;51	AEx					4
Rethorst et al., 2013155	AEx					1
Krogh et al. 2014152	AEx					0
Krogh et al., 2014163	AEx					4
Schuch et al., 2014164	AEx					2
Salehi et al., 201661	AEx					4
Carniero et al., 2017117	AEx					3
Euteneuer et al., 2017153	Ex					2
Kerling et al., 2017165	AEx					3
Lavebratt et al., 2017154	Ex-Vig					3
	Ex-Mod					3
	Ex-Light					3
Rahman et al., 2017166	Ex					2
Gourgouvelis et al., 2018167	Ex (AEx + REx)					4	AEx
							REx
Szuhany & Otto, 2020138	Ex					1
Gerber et al., 2020168	Ex					4

PA = physical activity; AEx = aerobic exercise; REx = resistance exercise; PREx = progressive resistance exercise; PHD = public health dose; 3d = 3 days/week; 5d = 5days/week; HI = high intensity; LO = low intensity; Psych = psychotherapy; P-AEx = progressive aerobic exercise; NP-AEx = non-progressive aerobic exercise; Ex = exercise; Ex-Vig = exercise-vigorous intensity; Ex-Mod = exercise-moderate intensity; Ex-Light = exercise-light intensity

Assessment of FITT variables

/ = sufficient/insufficient detail provided in manuscript to replicate the frequency (e.g. times per week), intensity (e.g., % heart rate reserve (AEx); % repetition maximum (REx), time (e.g., time spent exercising; time in target intensity zone), type (e.g. stationary cycling).

Assessment of intervention compliance with public health physical activity guidelines

= intervention required at least 150 minutes of moderate intensity AEx, or 75 minutes of vigorous intensity AEx, per week; and/or intervention required at least two days of REx (utilizing most muscle groups) per week.

= insufficient detail provided to determine total time and intensity; prescribed or reported time and intensity were below recommended thresholds.