Table 2.
Cross-sectional association of CBC phenotypes with Neuropsychological testing scores using linear mixed effect models. a
| Age >= 60 (n=1732) | Total sample (n=3290) | Age interaction | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Domain | Test b | CBC measures | Effect | 95% CI | p-value c | Effect d | 95% CI | p-value | p-value |
| Verbal Memory | LMD | NLR | −0.010 | (−0.06, 0.04) | 0.62 | −0.019 | (−0.06, 0.02) | 0.22 | 0.74 |
| RDW | −0.010 | (−0.07, 0.05) | 0.67 | −0.010 | (−0.06, 0.04) | 0.61 | 0.38 | ||
| MPV | −0.005 | (−0.07, 0.06) | 0.83 | −0.021 | (−0.07, 0.02) | 0.23 | 0.43 | ||
| PASD | NLR | −0.001 | (−0.05, 0.04) | 0.96 | −0.003 | (−0.04, 0.03) | 0.83 | 0.70 | |
| RDW | −0.001 | (−0.06, 0.05) | 0.95 | −0.007 | (−0.05, 0.03) | 0.66 | 0.85 | ||
| MPV | −0.023 | (−0.08, 0.03) | 0.29 | −0.009 | (−0.05, 0.03) | 0.57 | 0.16 | ||
| Visual Memory | VRD | NLR | −0.042 | (−0.09, 0.01) | 0.023 | −0.041 | (−0.08, −0.01) | 0.0032 | 0.74 |
| RDW | −0.050 | (−0.11, 0.01) | 0.029 | −0.032 | (−0.08, 0.01) | 0.064 | 0.020 | ||
| MPV | 0.008 | (−0.05, 0.07) | 0.71 | −0.018 | (−0.06, 0.02) | 0.27 | 0.31 | ||
| Executive Function | TRAILSBA | NLR | 0.034 | (−0.02, 0.08) | 0.079 | 0.036 | (−0.00, 0.07) | 0.015 | 0.43 |
| RDW | 0.039 | (−0.02, 0.10) | 0.11 | -- | (−0.03, 0.07) | 0.35 | 0.0084 | ||
| MPV | −0.044 | (−0.10, 0.02) | 0.058 | −0.026 | (−0.07, 0.02) | 0.12 | 0.28 | ||
|
SIM |
NLR | −0.037 | (−0.09, 0.01) | 0.045 | −0.029 | (−0.07, 0.01) | 0.053 | 0.013 | |
| RDW | −0.021 | (−0.08, 0.04) | 0.35 | −0.028 | (−0.08, 0.02) | 0.13 | 0.24 | ||
| MPV | 0.019 | (−0.04, 0.08) | 0.39 | 0.010 | (−0.03, 0.05) | 0.54 | 0.74 | ||
| DS | NLR | −0.039 | (−0.09, 0.01) | 0.056 | −0.033 | (−0.07, 0.00) | 0.019 | 0.31 | |
| RDW | −0.060 | (−0.12, 0.00) | 0.015 | −0.055 | (−0.10, −0.01) | 0.0012 | 0.27 | ||
| MPV | −0.010 | (−0.07, 0.05) | 0.67 | 0.019 | (−0.02, 0.06) | 0.22 | 0.068 | ||
| Visuospatial | HVOT | NLR | −0.049 | (−0.10, 0.00) | 0.011 | −0.048 | (−0.09, −0.01) | 0.0012 | 0.12 |
| RDW | −0.030 | (−0.09, 0.03) | 0.22 | −0.023 | (−0.07, 0.03) | 0.23 | 0.27 | ||
| MPV | 0.035 | (−0.03, 0.10) | 0.14 | -- | (−0.06, 0.03) | 0.29 | 0.0038 | ||
| Language | BNT30 | NLR | −0.019 | (−0.06, 0.03) | 0.27 | −0.022 | (−0.06, 0.01) | 0.11 | 0.17 |
| RDW | 0.009 | (−0.05, 0.07) | 0.67 | 0.013 | (−0.03, 0.06) | 0.48 | 0.029 | ||
| MPV | 0.016 | (−0.04, 0.07) | 0.45 | −0.008 | (−0.05, 0.03) | 0.62 | 0.23 | ||
CBC = complet blood count; CI = confidence interval; NLR = Neutrophil-to-lymphocyte ratio; RDW = red cell distribution width; MPV = mean platelet volume; LMD = Logical Memory - delayed recall; PASD = Paired Association learning - delayed recall; VRD = Visual Reproduction - delayed recall; TRAILSBA = Trails Making test B - Trails Making test A; SIM = Similarities subtest; DS = Digit Symbol coding test; HVOT = Hooper Visual Organization Test; BNT30 = 30 - item Boston Naming Test.
Model 1 covariates (age, sex, education level, cohort, time between blood draw and when the cognitive functioning were collected, prevalent CVD, C-reactive protein level, and APOE ε4 status, and retest indicator) were included.
Inverse normal transformation was applied on all Neuropsychological test scores.
p ≤ 0.01threshold to approximately account for the number of correlated neuropsychological test outcomes tested for each CBC measure.
The effect in the total sample without age interaction terms were reported. When significant age interaction terms between two groups were identified, effect estimates for the total sample were not reported.