Table 3.
Final population PK parameter estimates for piperacillin
| Parameter | Unit | Population estimate |
Standard error |
IIV |
|---|---|---|---|---|
| CLR | L/h per 69 mL/min CrCl | 4.09 | 16% | 47% |
| CLNR | L/h | 2.44 | 23% | |
| V | L per 89 kg WT | 31.8 | 11% | 25% |
| Proportional error | - | 35.8% | - | - |
| Additive Error | mg/L | 0.0488 | - | - |
CL, clearance; CrCl, creatinine clearance; CLNR, non-renal clearance; CLR, renal clearance; IIV, inter-individual variability; PK, pharmacokinetics; V, volume; WT, weight
Eta shrinkage was 8.8% for total clearance (CLR+CLNR) and 48% for V. The correlation between eta values for total clearance and volume was 52%.