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. Author manuscript; available in PMC: 2023 Feb 27.
Published in final edited form as: Clin Pharmacokinet. 2023 Jan 12;62(1):127–139. doi: 10.1007/s40262-022-01198-z

Table 4.

Final population PK parameter estimates for tazobactam

Parameter Unit Population
estimate		 Standard
error		 IIV
CLR L/h per 69 mL/min CrCl 5.18 12% 47%
CLNR L/h per 89 kg WT0.75 1.14 46%
V L per 89 kg WT 40.3 14% 21%
Proportional error - 30% - -
Additive error mg/L 0.562 - -

CL, clearance; CLNR, non-renal clearance; CLR, renal clearance; CrCl, creatinine clearance; IIV, inter-individual variability; PK, pharmacokinetics; V, volume; WT, weight

Eta shrinkage was 10% for total clearance (CLR+CLNR) and 61% for V. The correlation between eta values for total clearance and volume was 35%.