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Induction of micronuclei by lasiocarpine (A), riddelliine (B), and senkirkine (C) in CYP-expressing TK6 cells using a high-throughput micronucleus assay. The stopping gate was set to record 10,000 intact nuclei. Data were expressed as means ± SD from at least three independent experiments. * indicates P < 0.05 comparing treated groups to DMSO control. NR: not reported due to > 55% cytotoxicity in at least one independent experiment.
