Skip to main content
. 2023 Feb 23;64(2):23. doi: 10.1167/iovs.64.2.23

Table 3.

Significantly Regulated Proteins in CRVO versus Controls

Protein ID Protein Names Gene Names P Value Fold Change CRVO/Control
P02675 Fibrinogen beta chain FGB 8.28 × 10−13 10.20
P02671 Fibrinogen alpha chain FGA 6.56 × 10−12 9.96
P02679-2 Fibrinogen gamma chain FGG 3.74 × 10−13 8.68
P02656 Apolipoprotein C-III APOC3 3.55 × 10−8 6.00
P01871 Ig mu chain C region IGHM 0.010 3.74
P02751-1 Fibronectin FN1 4.96 × 10−14 3.52
P06312 Ig kappa chain V-IV region IGKV4-1 7.36 × 10−6 3.31
P04432 Ig kappa chain V-I region Daudi IGKV1-12 7.01 × 10−5 3.25
P01876 Ig alpha-1 chain C region IGHA1 3.60 × 10−6 2.97
P01031 Complement C5 C5 6.59 × 10−10 2.48
Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 ITIH4 1.5 × 10−9 2.28
P18428 Lipopolysaccharide-binding protein LBP 4.43 × 10−6 2.23
P06727 Apolipoprotein A-IV APOA4 9.91 × 10−8 2.22
P27169 Serum paraoxonase/arylesterase 1 PON1 4.4 × 10−5 2.14
P07360 Complement component C8 gamma chain C8G 1.92 × 10−7 2.08
P00734 Prothrombin F2 0.0035 2.06
P08603 Complement factor H CFH 9.47 × 10−9 2.05
P08697 Alpha-2-antiplasmin SERPINF2 7.57 × 10−9 2.03
P02647 Apolipoprotein A-I APOA1 1.5 × 10−6 2.02
P07358 Complement component C8 beta chain C8B 1.02 × 10−5 2.01
P05543 Thyroxine-binding globulin SERPINA7 2.33 × 10−5 1.98
P05546 Heparin cofactor 2 SERPIND1 5.19 × 10−9 1.97
P04004 Vitronectin VTN 1.67 × 10−7 1.97
P02792 Ferritin light chain FTL 0.012 1.96
P13671 Complement component C6 C6 4.68 × 10−5 1.95
P02750 Leucine-rich alpha-2-glycoprotein LRG1 0.0021 1.92
P19823 Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2 1.59 × 10−6 1.92
P01008 Antithrombin-III SERPINC1 3.78 × 10−9 1.91
P13796 Plastin-2 LCP1 0.0014 1.90
A0A0C4DH38 Immunoglobulin heavy variable 5–51 IGHV5-51 0.0053 1.89
P01042 Kininogen-1 KNG1 1.28 × 10−7 1.87
P03952 Plasma kallikrein KLKB1 5.27 × 10−5 1.85
P08185 Corticosteroid-binding globulin SERPINA6 9.34 × 10−8 1.85
P19827 Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 9.65 × 10−7 1.85
A0A075B6S5 Immunoglobulin kappa variable 1-27 IGKV1-27 0.00078 1.82
P10643 Complement component C7 C7 8.22 × 10−5 1.81
P02760 Protein AMBP AMBP 0.0011 1.80
A0A075B6J9 Immunoglobulin lambda variable 2-18 IGLV2-18 0.012 1.79
Q96IY4 Carboxypeptidase B2 CPB2 3.96 × 10−6 1.78
Q96PD5-2 N-acetylmuramoyl-L-alanine amidase PGLYRP2 4.11 × 10−5 1.77
P04217 Alpha-1B-glycoprotein A1BG 4.88 × 10−7 1.76
P0DOX2 Immunoglobulin alpha-2 heavy chain n/a 0.0014 1.76
P01024 Complement C3 C3 1.22 × 10−7 1.73
P06681 Complement C2 C2 2.15 × 10−6 1.72
P43652 Afamin AFM 3.01 × 10−6 1.72
P20396 Pro-thyrotropin-releasing hormone TRH 0.00051 1.71
P29622 Kallistatin SERPINA4 7.82 × 10−8 1.69
P35858 Insulin-like growth factor-binding protein complex acid labile subunit IGFALS 0.0028 1.69
P01009 Alpha-1-antitrypsin SERPINA1 1.17 × 10−5 1.67
P01011 Alpha-1-antichymotrypsin SERPINA3 1.15 × 10−5 1.66
P02748 Complement component C9 C9 0.0024 1.66
P04180 Phosphatidylcholine-sterol acyltransferase LCAT 0.00012 1.66
P02746 Complement C1q subcomponent subunit B C1QB 2.55 × 10−6 1.63
P01619 Ig kappa chain V-III region B6 IGKV3-20 0.015 1.62
P08571 Monocyte differentiation antigen CD14 CD14 2.1 × 10−6 1.61
Q14520-2 Hyaluronan-binding protein 2 HABP2 0.0038 1.61
P01023 Alpha-2-macroglobulin A2M 4.69 × 10−5 1.60
P19652 Alpha-1-acid glycoprotein 2 ORM2 0.00041 1.60
P04278-5 Sex hormone-binding globulin SHBG 0.032 1.60
P26927 Hepatocyte growth factor-like protein MST1 0.0010 1.56
P25311 Zinc-alpha-2-glycoprotein AZGP1 2.43 × 10−5 1.54
P0DOY3 Ig lambda-6 chain C region IGLC6 0.0013 1.54
P04196 Histidine-rich glycoprotein HRG 3.27 × 10−5 1.53
Q9UGM5 Fetuin-B FETUB 0.012 1.50
P02765 Alpha-2-HS-glycoprotein AHSG 0.00040 1.49
P02766 Transthyretin TTR 1.78 × 10−5 1.49
P01019 Angiotensinogen; angiotensin 1–9 AGT 1.62 × 10−5 1.47
P00748 Coagulation factor XII F12 0.012 1.46
P01859 Ig gamma-2 chain C region IGHG2 0.00020 1.44
P00747 Plasminogen PLG 0.0066 1.43
P51884 Lumican LUM 0.00012 1.41
P07357 Complement component C8 alpha chain C8A 0.020 1.33
P00450 Ceruloplasmin CP 8.38 × 10−6 1.32
P00751 Complement factor B CFB 0.0053 1.28
P05156 Complement factor I CFI 0.00020 1.25
P10909 Clusterin CLU 0.0060 0.78
Q9UBP4 Dickkopf-related protein 3 DKK3 0.0046 0.75
O00391-2 Sulfhydryl oxidase 1 QSOX1 0.0033 0.75
P18065 Insulin-like growth factor-binding protein 2 IGFBP2 0.015 0.74
P15291-2 Beta-1,4-galactosyltransferase 1 B4GALT1 0.013 0.72
P24592 Insulin-like growth factor-binding protein 6 IGFBP6 0.025 0.71
P10745 Retinol-binding protein 3 RBP3 0.015 0.70
P39060-2 Collagen alpha-1(XVIII) chain COL18A1 0.021 0.70
P16035 Metalloproteinase inhibitor 2 TIMP2 0.0029 0.69
Q6EMK4 Vasorin VASN 0.0046 0.69
P12109 Collagen alpha-1(VI) chain COL6A1 0.029 0.68
P61812 Transforming growth factor beta-2 TGFB2 0.035 0.68
P23471-3 Receptor-type tyrosine-protein phosphatase zeta PTPRZ1 0.0011 0.67
Q99435-4 Protein kinase C-binding protein NELL2 NELL2 0.020 0.66
Q99972 Myocilin MYOC 0.020 0.66
Q8N475 Follistatin-related protein 5 FSTL5 0.024 0.66
P10645 Chromogranin-A CHGA 0.018 0.66
P35443 Thrombospondin-4 THBS4 0.00030 0.66
Q7Z3B1 Neuronal growth regulator 1 NEGR1 0.00091 0.66
Q9BSG5 Retbindin RTBDN 0.012 0.66
P07195 L-lactate dehydrogenase B chain LDHB 0.024 0.65
Q9BY67-2 Cell adhesion molecule 1 CADM1 0.0015 0.65
P27797 Calreticulin CALR 0.011 0.65
P15586 N-acetylglucosamine-6-sulfatase GNS 0.014 0.64
P01034 Cystatin-C CST3 1.00 × 10−5 0.62
P41222 Prostaglandin-H2 D-isomerase PTGDS 0.00018 0.62
Q15582 Transforming growth factor-beta-induced protein ig-h3 TGFBI 1.00 × 10−5 0.62
P51693 Amyloid-like protein 1 APLP1 0.0016 0.62
Q14118 Dystroglycan DAG1 0.00073 0.62
P23142 Fibulin-1 FBLN1 3.17 × 10−6 0.62
Q9UBM4 Opticin OPTC 0.00037 0.61
P13591-5 Neural cell adhesion molecule 1 NCAM1 0.0013 0.61
Q92765 Secreted frizzled-related protein 3 FRZB 0.0042 0.60
Q15113 Procollagen C-endopeptidase enhancer 1 PCOLCE 0.0015 0.59
P10599 Thioredoxin TXN 0.0015 0.59
Q9HCB6 Spondin-1 SPON1 0.00011 0.59
Q16270 Insulin-like growth factor-binding protein 7 IGFBP7 3.82 × 10−5 0.58
Q99969 Retinoic acid receptor responder protein 2 RARRES2 5.53 × 10−5 0.58
P09486 SPARC SPARC 7.51 × 10−5 0.58
Q14055 Collagen alpha-2(IX) chain COL9A2 0.00010 0.57
P08123 Collagen alpha-2(I) chain COL1A2 0.00092 0.57
O43505 Beta-1,4-glucuronyltransferase 1 B4GAT1 0.00025 0.56
Q16769-2 Glutaminyl-peptide cyclotransferase QPCT 3.19 × 10−5 0.56
O75326 Semaphorin-7A SEMA7A 0.0014 0.56
Q8IZJ3-2 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 4.51 × 10−5 0.56
Q14515-2 SPARC-like protein 1 SPARCL1 2.48 × 10−5 0.56
P61916 Epididymal secretory protein E1 NPC2 0.00065 0.56
P80188 Neutrophil gelatinase-associated lipocalin LCN2 0.0030 0.56
O94985-2 Calsyntenin-1 CLSTN1 9.62 × 10−6 0.55
P19022 Cadherin-2 CDH2 1.95 × 10−5 0.55
Q96KN2 Beta-Ala-His dipeptidase CNDP1 0.00053 0.55
Q92520 Protein FAM3C FAM3C 6.77 × 10−6 0.55
P09972 Fructose-bisphosphate aldolase C ALDOC 0.0048 0.55
P12259 Coagulation factor V F5 0.014 0.55
Q9UHL4 Dipeptidyl peptidase 2 DPP7 6.89 × 10−5 0.55
Q12805-2 EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 7.20 × 10−6 0.54
Q12860 Contactin-1 CNTN1 0.00010 0.54
P05067 Amyloid-beta precursor protein APP 9.57 × 10−5 0.54
Q02818 Nucleobindin-1 NUCB1 7.89 × 10−5 0.54
Q9NQ79-3 Cartilage acidic protein 1 CRTAC1 6.22 × 10−5 0.53
Q9BRK5-6 45 kDa calcium-binding protein SDF4 4.82 × 10−6 0.53
Q12841 Follistatin-related protein 1 FSTL1 0.0039 0.52
Q9P121-3 Neurotrimin NTM 4.1 × 10−5 0.52
Q92823-3 Neuronal cell adhesion molecule NRCAM 3.63 × 10−5 0.51
P06733 Alpha-enolase ENO1 0.0020 0.50
P30086 Phosphatidylethanolamine-binding protein 1 PEBP1 7.09 × 10−8 0.50
P07686 Beta-hexosaminidase subunit beta HEXB 0.00014 0.50
P62987 Ubiquitin-60S ribosomal protein L40 UBA52 0.00022 0.50
Q14767 Latent-transforming growth factor beta-binding protein 2 LTBP2 0.00016 0.50
O15537 Retinoschisin RS1 0.019 0.49
P51888 Prolargin PRELP 0.0010 0.48
P11021 78 kDa glucose-regulated protein HSPA5 0.029 0.48
Q9BU40 Chordin-like protein 1 CHRDL1 5 × 10−5 0.47
Q9Y5W5 Wnt inhibitory factor 1 WIF1 8.91 × 10−5 0.46
P08294 Extracellular superoxide dismutase [Cu-Zn] SOD3 3.12 × 10−5 0.46
P62937 Peptidyl-prolyl cis-trans isomerase A PPIA 0.030 0.46
Q92563 Testican-2 SPOCK2 0.0016 0.46
O14773 Tripeptidyl-peptidase 1 TPP1 0.0039 0.46
P04075 Fructose-bisphosphate aldolase A ALDOA 0.0084 0.44
P16870-2 Carboxypeptidase E CPE 4.76 × 10−5 0.44
O95428-6 Papilin PAPLN 3.36 × 10−5 0.43
Q13822 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 ENPP2 2.86 × 10−6 0.43
P14618 Pyruvate kinase PKM PKM 0.00020 0.42
Q08380 Galectin-3-binding protein LGALS3BP 1.16 × 10−5 0.42
Q99574 Neuroserpin SERPINI1 1.36 × 10−7 0.42
P78509 Reelin RELN 0.0044 0.41
P31025 Lipocalin-1 LCN1 0.00016 0.41
P98164 Low-density lipoprotein receptor-related protein 2 LRP2 0.00011 0.41
P63104 14-3-3 protein zeta/delta YWHAZ 0.015 0.41
P09211 Glutathione S-transferase P GSTP1 0.0016 0.40
Q7Z7G0 Target of Nesh-SH3 ABI3BP 2.71 × 10−5 0.39
Q02413 Desmoglein-1 DSG1 5.25 × 10−5 0.39
Q06481 Amyloid-like protein 2 APLP2 1.68 × 10−5 0.38
Q08554-2 Desmocollin-1 DSC1 5.81 × 10−5 0.37
Q08629 Testican-1 SPOCK1 2.00 × 10−7 0.36
P98160 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 3.48 × 10−6 0.36
O00468-6 Agrin AGRN 5.27 × 10−6 0.33
Q9NZT1 Calmodulin-like protein 5 CALML5 0.0086 0.32
P00558 Phosphoglycerate kinase 1 PGK1 5.74 × 10−6 0.30
P35555 Fibrillin-1 FBN1 1.32 × 10−8 0.28
P15924 Desmoplakin DSP 0.0014 0.22
P22914 Beta-crystallin S CRYGS 2.65 × 10−7 0.20