Table 3.

Association between MDD, LLD or DS and neuropathological alterations (n = 741) in CDR = 0 and CDR = 0.5 cases.

	Small vessel disease		Crude OR (95% CI)	p	Multivariate^a OR (95% CI)	p	Multivariate^b OR (95% CI)	p
	No	Yes	Crude OR (95% CI)	p	Multivariate^a OR (95% CI)	p	Multivariate^b OR (95% CI)	p

a-MDD × no MDD	46 (85.2%) 549 (90.9%)	8 (14.8%) 55 (9.1%)	1.7 (0.8–3.9)	0.18	2.5 (1.1–5.9)	0.037	2.7 (1.1–6.8)	0.039
LLD × no MDD	57 (80.3%) 549 (90.9%)	14 (19.7%) 55 (9.1%)	2.6 (1.5–4.9)	0.001	2.4 (1.3–4.5)	0.005	2.7 (1.4–5.2)	0.003
DS × no DS	141 (83.9%) 516 (90.7%)	27 (16.1%) 53 (9.3%)	1.8 (1.1–3.1)	0.013	2.0 (1.2–3.3)	0.007	2.3 (1.3–4.0)	0.003
	Cerebral amyloid angiopathy
	No	Yes
a-MDD × no MDD	53 (98.1%) 582 (96.5%)	1 (1.9%) 21 (3.5%)	0.5 (0.1–4.0)	0.53	0.4 (0.1–2.9)	0.35	0.4 (0.1–3.4)	0.39
LLD × no MDD	67 (94.4%) 582 (96.5%)	4 (5.6%) 21 (3.5%)	1.6 (0.6–5.0)	0.32	1.3 (0.5–4.2)	0.57	2.0 (0.6–6.4)	0.24
DS × no DS	160 (95.2%) 550 (96.8%)	8 (4.8%) 18 (3.2%)	1.5 (0.7–3.6)	0.33	1.5 (0.6–3.4)	0.40	2.1 (0.8–5.2)	0.13
	Infarcts
	No	Yes
a-MDD × no MDD	51 (94.4%) 566 (94.0%)	3 (5.6%) 36 (6.0%)	0.9 (0.3–3.1)	0.90	1.2 (0.3–4.2)	0.82	0.6 (0.1–4.4)	0.58
LLD × no MDD	59 (83.1%) 566 (94.0%)	12 (16.9%) 36 (6.0%)	3.2 (1.6–6.5)	0.001	2.5 (1.3–5.1)	0.009	2.7 (1.2–5.8)	0.012
DS × no DS	146 (88.0%) 537 (94.4%)	20 (12.0%) 32 (5.6%)	2.3 (1.3–4.2)	0.005	2.2 (1.3–4.2)	0.008	2.3 (1.2–4.5)	0.018
	Neuritic plaques (beta-amyloid): moderate-frequent
	No	Yes
a-MDD × no MDD	51 (94.4%) 500 (82.4%)	3 (5.6%) 107 (17.6%)	0.3 (0.1–0.9)	0.032	0.4 (0.1–1.5)	0.19	0.5 (0.1–1.7)	0.25
LLD × no MDD	59 (83.1%) 500 (82.4%)	12 (16.9%) 107 (17.6%)	1.0 (0.5–1.8)	0.88	0.8 (0.4–1.5)	0.41	0.8 (0.4–1.6)	0.53
DS × no DS	135 (80.4%) 482 (84.3%)	33 (19.6%) 90 (15.7%)	1.3 (0.8–2.0)	0.23	1.4 (0.9–2.2)	0.18	1.4 (0.9–2.4)	0.17
	Neurofibrillary pathology (tau) III-VI
	No	Yes
a-MDD × no MDD	44 (81.5%) 433 (72.3%)	10 (18.5%) 166 (27.7%)	0.6 (0.3–1.2)	0.15	1.2 (0.5–2.7)	0.66	1.2 (0.5–2.9)	0.70
LLD × no MDD	48 (60.0%) 433 (72.3%)	32 (40.0%) 166 (27.7%)	1.7 (1.1–2.8)	0.023	1.2 (0.8–2.2)	0.34	1.2 (0.7–2.2)	0.45
DS × no DS	109 (65.3%) 416 (73.6%)	58 (34.7%) 149 (26.4%)	1.4 (1.0–2.1)	0.035	1.7 (1.1–2.5)	0.018	1.5 (1.0–2.4)	0.06
	Lewy body disease
	No	Yes
a-MDD × no MDD	48 (90.6%) 531 (91.4%)	5 (9.4%) 50 (8.6%)	1.1 (0.4–2.9)	0.84	1.8 (0.6–4.9)	0.28	2.1 (0.7–6.1)	0.16
LLD × no MDD	57 (81.4%) 531 (91.4%)	13 (18.6%) 50 (8.6%)	2.4 (1.2–4.7)	0.008	1.9 (0.9–3.6)	0.07	2.0 (1.0–4.1)	0.043
DS × no DS	138 (84.1%) 506 (92.3%)	26 (15.9%) 42 (7.7%)	2.3 (1.3–3.8)	0.002	2.4 (1.4–4.1)	0.001	2.5 (1.4–4.4)	0.002

Key: a-MDD, adult-onset major depressive disorder; 95% CI, 95% Confidence Interval; DS, depressive symptoms 3 months prior to death; LLD, late life MDD; MDD, major depressive disorder.

Logistic regression models adjusted for CDR, age at death, sex, and ethnicity.

Logistic regression models adjusted for CDR, age at death, sex, ethnicity, alcohol misuse, smoking, hypertension, diabetes mellitus, and dyslipidemia.