Table 1. Gastric and other gastrointestinal cancers (N = 4).
| Study name; author (year) | Study
type/size |
HALP threshold
(method) |
Outcome(s) | Summary |
|---|---|---|---|---|
| Prognostic significance of the
combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study; Chen et al., (2015) |
Retrospective
N = 1332 |
56.8 (X-tile) | OS in Gastric Cancer patients
who underwent gastrectomy. |
Patients who had high HALP ≥56.8
were shown to have smaller tumor size and less advanced tumor stage. High HALP patients also had superior overall survival. HALP was more accurate in prognostic prediction than TNM stage alone. |
| A novel robust nomogram based
on preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) for predicting lymph node metastasis of gastric cancer; Wang et al., (2021) |
Retrospective
N = 349 |
35.3 (ROC) | Predicting Lymph node metastasis
of gastric cancer. |
HALP was an independent risk factor
for lymph node metastasis, which was used as part of a nomogram in addition to alcohol use, depth of invasion, differentiation, CEA, and CA19-9. |
| Haemoglobin, albumin, lymphocyte
and platelet predicts postoperative survival in pancreatic cancer; Xu et al., (2020) |
Prospective
N = 582 |
44.56 (X-tile) | OS and RFS in pancreatic
adenocarcinoma who underwent radical resection. |
Patients with HALP <44.56 were
found to be more likely to have lymph node metastasis, poor tumor differentiation, and high TNM staging. Low HALP was also a significant predictor of worse overall survival and worse recurrence-free survival. |
| Comparison of Prognostic Value
of Red Cell-Related Parameters of Biliary Tract Cancer After Surgical Resection and Integration of a Prognostic Nomogram: A Retrospective Study; Sun et al., (2021) |
Retrospective
N = 418 |
42.68 (X-tile) | OS in surgical resection in patients
with biliary tract cancer – integrated into a prognostic nomogram. |
HALP > 42.68 an independent
predictor of better overall survival, and outperformed other parameters tested. Nomogram which included both TNM Staging and HALP outperformed TNM alone. |