Table 2. Colorectal summary (N = 5).

Study name; author (year)	Study type/size	HALP threshold (method)	Outcome(s)	Summary
Preoperative combined hemoglobin, albumin, lymphocyte and platelet levels predict survival in patients with locally advanced colorectal cancer; Jiang et al., (2016)	Prospective N = 820	26.5 (X-tile)	OS and CSS in locally advanced colorectal cancer.	Low HALP conferred worse prognostic 5-year OS and CSS in patients with locally advanced colorectal cancer.
Prognostic significance of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients undergoing curative resection for colorectal cancer; Yalav et al., (2021)	Retrospective N = 279	15.7 (ROC)	OS and Post-operative complications.	HALP score > 15.7 is closely related to clinic pathological features and is an independent prognostic factor for overall survival. Its value in estimating mean survival is limited. Postoperative outcomes were similar between groups.
The Efficacy of Hemoglobin, Albumin, Lymphocytes, and Platelets as a Prognostic Marker for Survival in Octogenarians and Nonagenarians Undergoing Colorectal Cancer Surgery; Dagmura et al., (2021)	Prospective N = 139	15.5 (ROC)	OS in patients undergoing curative colorectal cancer surgery.	Low HALP biomarker was associated with worse prognosis of patients treated surgically for colorectal cancer with curative intent. Furthermore, HALP score was significantly different in octogenarians compared to their younger counterparts.
Can HALP (Hemoglobin, Albumin, Lymphocytes, and Platelets) Score Differentiate Between Malignant and Benign Causes of Acute Mechanic Intestinal Obstruction?; Akbas et al., (2021)	Retrospective N = 192	23.94 (ROC)	Benign vs. Malignant causes of acute mechanical intestinal obstruction.	HALP <23.94 was an independent prognostic variable for predicting malignant causes of acute mechanical intestinal obstruction.
Diagnostic Value of Preoperative Haemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score in Predicting Tumour Budding in Colorectal Cancer; Topal et al., (2022)	Retrospective N = 110	31.6 (ROC)	Predicting the presence or absence of tumor budding in patients undergoing surgery.	HALP score was not statistically significantly associated with the presence or absence of tumor budding.