Table 8. Esophageal and pharyngeal cancer summary (N = 5).

Study name (year)	Study type/size	HALP threshold (method)	Outcome(s)	Summary
The value of the combination of hemoglobin, albumin, lymphocyte and platelet in predicting platinum- based chemoradiotherapy response in male patients with esophageal squamous cell carcinoma; Cong et al., (2017)	Retrospective N = 39	48.34 (Median)	OS, Chemotherapy Response, and PFS in inoperable esophageal squamous cell carcinoma patients.	Patients with HALP >48.34 were shown to have increased complete response to chemotherapy and have improved PFS. No differences in OS were observed between High and Low HALP.
The preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) score is a useful predictor in patients with resectable esophageal squamous cell carcinoma; Feng et al., (2021)	Retrospective N = 355	31.8 (ROC)	CSS in resectable patients undergoing curative resection for esophageal squamous cell carcinoma.	Patients with HALP >31.8 had superior 5-year CSS. Low HALP predicted worse OS when stratifying by Tumor Staging: TNM I, TNM II, and TNM III.
Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma; Hu et al., (2021)	Prospective N = 756	38.8 (ROC)	OS in patients who underwent radical esophagectomy with R0 resection.	Patients with HALP <38.8 had worse OS than patients HALP ≥38.8. Low HALP was associated with worse tumor characteristics.
Nutritional status at diagnosis is prognostic for pharyngeal cancer patients: a retrospective study; Wu et al., (2022)	Retrospective N = 319	44 (Mean)	OS and CSS based on HALP score at time of diagnosis in pharyngeal cancer patients.	Low HALP <44 predicted worse OS. HALP did not predict CSS, but was nearly significant.
Comprehensive risk evaluation for metachronous carcinogenesis after endoscopic submucosal dissection of superficial pharyngeal squamous cell carcinoma; Ogasawara et al., (2022)	Retrospective N = 144	40 (Median)	Predict the risk of metachronous carcinogenesis after endoscopic submucosal dissection in superficial pharyngeal squamous cell carcinoma.	Patients with Low HALP <40 were found to have over 3x increased risk of developing metachronous pharyngeal squamous cell carcinoma.