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. 2023 Feb 27;19:17. doi: 10.1186/s13223-023-00770-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A flow chart and checklist of a virtually supported penicillin oral challenge. A Visit 1: virtual consultation and preparation. B Visit 2: virtually supported home amoxicillin oral provocation challenge. (1) Immediate reaction is defined as Type I hypersensitivity reaction that is IgE mediated and occurs within 2 h of the first dose of medication and lasts < 24 h. (2) Delayed hypersensitivity reaction are defined as Type II–IV reactions that typically take > 24 h to develop and raise concern for end organ involvement (cytopenias, renal/hepatic dysfunction, serum sickness), or severe cutaneous adverse reactions (skin desquamation, purpura, mucosal lesions, SJS/TEN, DRESS, AGEP)

(Figure adapted from Mack et al. [8]. JACI: In Practice)

Fig. 1 — A flow chart and checklist of a virtually supported penicillin oral challenge. A Visit 1: virtual consultation and preparation. B Visit 2: virtually supported home amoxicillin oral provocation challenge. (1) Immediate reaction is defined as Type I hypersensitivity reaction that is IgE mediated and occurs within 2 h of the first dose of medication and lasts < 24 h. (2) Delayed hypersensitivity reaction are defined as Type II–IV reactions that typically take > 24 h to develop and raise concern for end organ involvement (cytopenias, renal/hepatic dysfunction, serum sickness), or severe cutaneous adverse reactions (skin desquamation, purpura, mucosal lesions, SJS/TEN, DRESS, AGEP)

(Figure adapted from Mack et al. [8]. JACI: In Practice)