Table 2. Odds ratios and 95% confidence intervals for the association between epigenetic age acceleration (using 3 different measures) and the risk of lung cancer in the CLUE II study.

Age acceleration measure	OR (95% CI)*	p-value*
AA_Hannum
Q1	1 (ref.)
Q2	0.96 (0.55, 1.66)	0.88
Q3	0.74 (0.42, 1.30)	0.29
Q4	0.74 (0.42, 1.31)	0.31
Continuous (per 1 SD)	0.82 (0.64, 1.05)	0.12
AA_Horvath
Q1	1 (ref.)
Q2	0.80 (0.46, 1.41)	0.45
Q3	0.65 (0.37, 1.16)	0.15
Q4	0.76 (0.43, 1.33)	0.33
Continuous (per 1 SD)	0.85 (0.68, 1.07)	0.17
AA_Pheno
Q1	1 (ref.)
Q2	0.61 (0.33, 1.11)	0.10
Q3	0.79 (0.44, 1.40)	0.42
Q4	0.89 (0.51, 1.56)	0.69
Continuous (per 1 SD)	0.92 (0.76, 1.10)	0.36
IEAA_Hannum
Q1	1 (ref.)
Q2	0.74 (0.42, 1.31)	0.30
Q3	0.62 (0.35, 1.10)	0.10
Q4	0.70 (0.40, 1.24)	0.22
Continuous (per 1 SD)	0.87 (0.67, 1.14)	0.33
IEAA_Horvath
Q1	1 (ref.)
Q2	0.52 (0.28, 0.94)	0.031
Q3	0.84 (0.48, 1.47)	0.54
Q4	0.82 (0.47, 1.42)	0.47
Continuous (per 1 SD)	0.93 (0.73, 1.19)	0.58
IEAA_Pheno
Q1	1 (ref.)
Q2	0.75 (0.42, 1.35)	0.33
Q3	0.92 (0.52, 1.65)	0.79
Q4	0.87 (0.49, 1.55)	0.64
Continuous (per 1 SD)	0.90 (0.74, 1.10)	0.30

Abbreviations: IEAA: Intrinsic epigenetic age acceleration; ref.: referent. ^*Conditional logistic regression models, adjusting for batch effects, BMI, and smoking predicted pack years (using DNA methylation).