Table 3. Odds ratios and 95% confidence intervals for the association between epigenetic age acceleration (using 3 different measures) and the risk of lung cancer in the CLUE II study, stratified by time between blood draw and cancer diagnosis (in cases; matched date in controls).

	Time difference ≤10 yrs		Time difference >10 yrs
	OR (95% CI)*	p-value*	OR (95% CI)*	p-value*
AA_Hannum
Q1	1 (ref.)		1 (ref.)
Q2	1.38 (0.62, 3.07)	0.43	0.79 (0.42, 1.48)	0.46
Q3	1.09 (0.49, 2.43)	0.84	0.61 (0.31, 1.17)	0.14
Q4	0.70 (0.29, 1.66)	0.41	0.77 (0.41, 1.45)	0.41
		p for trend = 0.34		p for trend = 0.33
AA_Horvath
Q1	1 (ref.)		1 (ref.)
Q2	0.75 (0.33, 1.69)	0.48	0.77 (0.41, 1.46)	0.43
Q3	0.66 (0.28, 1.51)	0.32	0.62 (0.32, 1.20)	0.15
Q4	0.74 (0.33, 1.64)	0.46	0.75 (0.39, 1.41)	0.37
		p for trend = 0.44		p for trend = 0.30
AA_Pheno
Q1	1 (ref.)		1 (ref.)
Q2	0.84 (0.36, 1.99)	0.69	0.53 (0.26, 1.06)	0.07
Q3	1.35 (0.59, 3.07)	0.48	0.59 (0.30, 1.16)	0.13
Q4	0.67 (0.28, 1.58)	0.36	1.06 (0.56, 1.98)	0.86
		p for trend = 0.54		p for trend = 0.69
IEAA_Hannum
Q1	1 (ref.)		1 (ref.)
Q2	0.61 (0.26, 1.42)	0.25	0.75 (0.40, 1.41)	0.37
Q3	0.91 (0.42, 1.94)	0.80	0.50 (0.25, 1.00)	0.05
Q4	0.58 (0.26, 1.34)	0.20	0.74 (0.39, 1.42)	0.37
		p for trend = 0.35		p for trend = 0.28
IEAA_Horvath
Q1	1 (ref.)		1 (ref.)
Q2	0.39 (0.15, 0.97)	0.044	0.58 (0.30, 1.14)	0.11
Q3	0.90 (0.40, 2.01)	0.79	0.81 (0.43, 1.53)	0.52
Q4	0.82 (0.37, 1.80)	0.62	0.77 (0.41, 1.44)	0.41
		p for trend = 0.93		p for trend = 0.59
IEAA_Pheno
Q1	1 (ref.)		1 (ref.)
Q2	0.84 (0.36, 1.98)	0.70	0.66 (0.34, 1.31)	0.24
Q3	1.27 (0.56, 2.89)	0.57	0.81 (0.41, 1.60)	0.54
Q4	0.59 (0.25, 1.41)	0.24	1.06 (0.55, 2.03)	0.86
		p for trend = 0.33		p for trend = 0.67

Abbreviations: IEAA: Intrinsic epigenetic age acceleration; ref.: referent. ^*Conditional logistic regression models, adjusting for batch effects, BMI, and smoking predicted pack years (using DNA methylation).