Table 4. Odds ratios and 95% confidence intervals for the association between epigenetic age acceleration (using 3 different measures) and the risk of lung cancer in the CLUE II study, stratified by sex.

	Female		Male
	OR (95% CI)	p-value	OR (95% CI)	p-value
AA_Hannum
Q1	1 (ref.)		1 (ref.)
Q2	0.74 (0.28, 2.00)	0.56	0.78 (0.30, 2.00)	0.60
Q3	1.18 (0.49, 2.84)	0.71	0.50 (0.21, 1.19)	0.12
Q4	0.79 (0.33, 1.88)	0.60	0.29 (0.10, 0.80)	0.017
		P trend = 0.78		P trend =0.015
AA_Horvath
Q1	1 (ref.)		1 (ref.)
Q2	0.92 (0.40, 2.13)	0.84	0.72 (0.30, 1.73)	0.47
Q3	0.82 (0.34, 1.99)	0.66	0.51 (0.21, 1.24)	0.14
Q4	0.92 (0.40, 2.15)	0.85	0.50 (0.19, 1.35)	0.17
		P trend = 0.80		P trend = 0.13
AA_Pheno
Q1	1 (ref.)		1 (ref.)
Q2	0.70 (0.28, 1.76)	0.44	1.11 (0.43, 2.86)	0.83
Q3	0.89 (0.38, 2.05)	0.78	0.90 (0.36, 2.26)	0.83
Q4	0.93 (0.40, 2.16)	0.86	0.60 (0.21, 1.74)	0.35
		P trend = 0.97		P trend = 0.30
IEAA_Hannum
Q1	1 (ref.)		1 (ref.)
Q2	1.27 (0.52, 3.08)	0.60	0.31 (0.11, 0.82)	0.018
Q3	1.17 (0.47, 2.93)	0.74	0.37 (0.14, 0.96)	0.041
Q4	0.92 (0.40, 0.10)	0.84	0.35 (0.13, 0.92)	0.034
		P trend = 0.68		P trend = 0.03
IEAA_Horvath
Q1	1 (ref.)		1 (ref.)
Q2	0.85 (0.36, 2.00)	0.70	0.85 (0.34, 2.15)	0.73
Q3	0.73 (0.31, 1.75)	0.48	0.83 (0.33, 2.11)	0.70
Q4	0.21 (0.54, 2.74)	0.64	0.53 (0.17, 1.58)	0.25
		P trend = 0.65		P trend = 0.28
IEAA_Pheno
Q1	1 (ref.)		1 (ref.)
Q2	1.01 (0.43, 2.36)	0.98	1.34 (0.51,3.52)	0.55
Q3	1.10 (0.46, 2.63)	0.83	1.18 (0.46, 3.05)	0.73
Q4	1.04 (0.46, 2.35)	0.92	0.63 (0.21, 1.82)	0.39
		P trend = 0.88		P trend = 0.38

Abbreviations: IEAA: Intrinsic epigenetic age acceleration; ref.: referent. ^*Conditional logistic regression models, adjusting for batch effects, BMI, and smoking predicted pack years (using DNA methylation).