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. 2023 Feb 4;31:512–524. doi: 10.1016/j.omtn.2023.01.017

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© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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BM-MSCs^PRL-1 enhanced anaerobic metabolism by improving hepatic function in the cirrhotic rat liver

(A) Schematic diagram showing anaerobic metabolism in liver mitochondria. (B) The concentrations of LDH and cytoplasmic and mitochondrial lactate among individual liver proteins (n = 3–4/group). (C) Western blot analysis of mitochondrial respiration markers (e.g., Pdh, Sdha, and Atp5b) in pooled liver samples (n = 5–6/group). (D) mtDNA copy number and ATP production in individual liver proteins (n = 3–4/group). (E) mRNA expression of Prl-1 and Alb in pooled liver samples (n = 5–6/group). (F) Protein expression of albumin and cell cycle markers (e.g., Cdk4 and Cyclin D1) in pooled liver samples (n = 5–6/group). Values represent the mean ± SD. ∗p < 0.05 in comparison with the NTx group. ∗∗p < 0.05 in comparison with BM-MSCs.