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. 2023 Feb 4;31:512–524. doi: 10.1016/j.omtn.2023.01.017

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© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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PRL-1 modulates anaerobic metabolism through mitochondria in hepatocytes

(A) Immunofluorescence analysis of LDH (red) and MitoTracker (green) in LCA-injured hepatocytes cocultured with BM-MSCs^PRL−1 upon treatment with pentamidine (1 μg/mL). The concentrations of (B) cytosolic and (C) mitochondrial lactate in hepatocytes. (D) mtDNA copy number in the gDNA determined using TaqMan assay. (E) Assay of ATP production using cell lysates (10 μg/μL). (F) Protein expression of mitochondrial respiration markers in hepatocytes. Values represent the mean ± SD. ^#p < 0.05 in comparison with the control (−) group; ∗p < 0.05 in comparison with the LCA group; ∗∗p < 0.05 in comparison with the coculture groups; ^$p < 0.05 in comparison with the untreated groups.