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. 2023 Feb 2;4(2):181–202. doi: 10.1038/s43018-022-00510-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Forest plots showing the association between fCNV amplification/mutation status of GBM driver oncogenes and subtype transcriptomic activity (magenta) or abundance of protein of the corresponding gene (light blue) in the CPTAC-GBM cohort (n = 84 GBM samples; univariate logistic regression). log(odd ratio) estimates (OR), 95% confidence intervals (CI) and P values are reported. log(OR) estimates higher/lower than 0 represent positive/negative association. b, FGFR3-TACC3 fusion analysis was performed using a cohort of GBM profiled by FFPE tissue RNA-Seq (n = 170 GBM samples; univariate logistic regression). log(OR) estimates, 95% CI and P values are reported. c, Forest plots showing the association between fCNV deletion/mutation status in GBM tumor suppressor genes and subtype transcriptomic activity (blue) or protein abundance of the corresponding gene (light blue; n = 84 GBM samples; univariate logistic regression). log(OR) estimates, 95% CI and P values are reported. For tumor suppressor genes, subtype activity values (NES) were multiplied by −1 for visualization purposes.