Table 2.

Characterization of the studied FLG SNPs in SCAALA Brazilian cohort.

SNP	Position	A1	A2	Non-eczema	Eczema	Function	RegulomeDB Rank
rs115053459	152274909	T	C	0.02	0.01	Utr variant 3 prime	6
rs76330665	152275273	T	G	0.02	0.01	Missense	3b
rs3814299	152275453	A	G	0.01	0.02	Missense	3a
rs3126065	152275559	G	A	0.20	0.22	Missense	5
rs78733053	152275644	A	G	0.02	0.01	Synonymous codon	5
rs62623409	152281745	T	G	0.01	0.01	Missense	4
rs74129458	152281876	C	T	0.02	<0.01	Missense	4
rs12405278	152282267	A	G	0.14	0.11	Missense	5
rs151103850	152282684	A	G	0.01	0.01	Missense	5
rs76586335	152284673	A	G	0.02	<0.01	Missense, upstream variant 2 KB	3a
rs77032592	152285002	A	G	0.02	0.01	Missense, upstream variant 2 KB	5
rs114762657	152285290	T	C	0.04	0.02	Missense, upstream variant 2 KB	5
rs74129464	152285759	G	A	0.02	<0.01	Missense, upstream variant 2 KB	4
rs11588170	152286032	T	C	0.14	0.11	Missense	5
rs76438926	152287078	A	G	0.04	0.03	Intron variant, missense	4
rs115489580	152287213	C	T	0.04	0.03	Missense, nc transcript variant	6
rs76385639	152289573	A	C	0.02	0.01	Intron variant	3a
rs6587666	152296863	T	C	0.23	0.16	Intron variant	7

^aSNP, single nucleotide polymorphism; ^bPosition, location (assembly GRCh37.p13); ^cA1, minor allele; ^dA2, ancestral allele; ^eMAF, minor allele frequency; ^fRegulomeDB rank refers to: 3a: TF binding + any motif + DNase peak; 3b: TF binding + matched TF motif; 4: TF binding + DNase peak; 5: TF binding or DNase peak; 6: Motif hit; 7: Other.