Table 1.
Inhibition of viral infectivity. BHK-21 cells were infected with HCoV-OC43 (MOI = 0.1), and treated with compounds (10 μM) for 3 days. The table shows log10 reduction in TCID50/ml compared to the DMSO (negative) control (n = 3; mean ± standard error). Significance of differences was determined by ANOVA with Tukey’s multiple comparisons; ns, not significant; *, p ≤ 0.05; **, p ≤ 0.001.
| Compound | log10 reduction in infectivity (mean ± SEM) |
|---|---|
| xanthone | 2.04±0.58 |
| mangiferin | 3.00±0.60 ** |
| 5 | 2.50±0.70 * |
| 6 | 2.00±0.37 |
| 7 | 1.95±0.28 ** |
| 8 | 2.20±0.23 ** |
| 10 | 2.42±0.56 |
| 11 | 2.79±0.48 * |
| 12 | 2.67±0.51 * |
| 13 | 2.67±0.42 * |
| 14 | 2.38±0.47 |
| 15 | 1.95±0.25 ** |
| 16 (R = H) | 2.45±0.19 ** |