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. 2021 Oct 12;25(1):122–132. doi: 10.1007/s11307-021-01657-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — In vivo fluorescence imaging of orthotopic BxPC-3 pancreas adenocarcinomas with uIgG-800F, uFab2-800F, and uFab-800F during the optimal time period: a NIR images of orthotopic BxPC-3 pancreas adenocarcinomas taken with the Artemis clinical camera 96 h are uIgG-800F (left panel), 48 h are uFab2-800F (middle panel), and 36 h after uFab-800F (left panel) administration. Tumors are identified with a yellow arrow and kidney fluorescence, when present, with a red arrow. Note the lower exposure time needed after uIgG-800F administration reflecting a higher MFI. b TBRs and c tumor MFIs measured using the Pearl do not differ significantly between uIgG-800F, uFab2-800F, and uFab-800F at respectively 96 h, 48 h,and 36 h after injection. a.u., arbitrary units; hrs, hours; MFI, mean fluorescence intensity; ns, not significant; TBR, tumor-to-background ratio; T, time.