Table 4.
Hazard ratios of mortality by isoflavone intake groups.
| Total isoflavones (mg/day) | < 0.010 | ≥ 0.010 | |
|---|---|---|---|
| Case number (n) | 7,187 | 6,842 | |
| Person-years | 55,194 | 52,571 | |
| HR (95%CI) | p value | ||
| All-cause mortality | |||
| Model 1 (unadjusted) | 1 | 0.66 (0.58, 0.76) | <0.001 |
| Model 2 (adjusted for age and PIR) | 1 | 0.74 (0.64, 0.86) | <0.001 |
| Model 3 (multivariate) | 1 | 0.81 (0.70, 0.94) | 0.01 |
| Heart disease mortality | |||
| Model 1 (unadjusted) | 1 | 0.62 (0.47, 0.81) | <0.001 |
| Model 2 (adjusted for age and PIR) | 1 | 0.70 (0.53, 0.91) | 0.01 |
| Model 3 (multivariate) | 1 | 0.75 (0.56, 1.01) | 0.06 |
| Cerebrovascular disease mortality | |||
| Model 1 (unadjusted) | 1 | 1.09 (0.69, 1.71) | 0.71 |
| Model 2 (adjusted for age and PIR) | 1 | 1.26 (0.78, 2.03) | 0.34 |
| Model 3 (multivariate) | 1 | 1.30 (0.76, 2.20) | 0.34 |
Hazard ratios (95% CI) for all-cause, heart disease, and cerebrovascular disease mortality were analyzed using Cox proportional hazard models. Model 1 was unadjusted; Model 2 was adjusted for age and PIR; and Model 3 was adjusted for age, PIR, sex, education status, race, BMI, daily energy intake, smoking status, alcohol intake, total time of PA, and hyperlipidemia.
PIR, poverty income ratio; BMI, body mass index; PA, physical activity.