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Mechanisms of radioresistance caused by DNA damage repair in NSCLC. Radiation induced DNA damage response can activate the DNA repair pathway, of which SSBs can be repaired through ATR/Chk1 pathway and PARP1, DSBs can be repaired through NHEJ and HR. In the red box are proteins related to the repair of DSBs that may become new targets for radiosensitization. The solid line represents a clear target, and the dotted line represents a possible action through this target.
