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. 2023 Feb 14;14:1117762. doi: 10.3389/fphar.2023.1117762

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Copyright © 2023 Luo, Wang, Zhang, Zeng, Yi, Li, Pan, Zhu, Lin, Liang, Verkhratsky and Nie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of administration of PPVI on the foot swelling of CFA-induced chronic neuroinflammatory pain mice. (A) The foot swelling of mice in each group was detected on the 12 days after CFA injection. (B) The foot swelling of mice in each group was detected on the day before CFA injection, 1, 3, and 5 days after injection, and 1, 3, 5, and 7 days after PPVI administration, n = 10 in each group. (C) The foot swelling of mice in each group was detected 12 days after the CFA injection. Data are presented as mean ± S.E.M, significant differences among different groups are indicated as ###p < 0.001, vs. control; *p < 0.05 vs. CFA group.