TABLE 3.

Affinities and amino acid sites of ligand-protein detected by molecular docking.

Protein	Ligand	Binding energy kcal/mol	Amino acid binding site
P2X3	Dioscin	−12.0	ARG295/281, TYR285, TRP152, GLY129/130
	Polyphyllin H	−11.7	ARG295/529, GLN102, TRP152, GLU109
	Polyphyllin I	−11.6	TYR285, ARG295, GLN102, TRP152
	Polyphyllin V	−11.2	GLU109/156, GLY129/130, ARG295, TYR285
	Polyphyllin VI	−10.8	ARG295/281, TYR285, TRP152, GLY129/130
	Polyphyllin F	−10.6	ARG295/281, TYR285, TRP152, GLU109
	Gracillin	−5.7	ARG25, GLY314, ASP248