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. 2023 Feb 27;6:224. doi: 10.1038/s42003-023-04584-w

Fig. 2. Manhattan plots of the epigenome-wide DNAm associated with GA in START (n = 953).

Fig. 2

a Results from the conventional EWAS where we adjusted for the estimated cell-type proportions (see Methods for details of the statistical model). bh Results for each of the seven cell types from the cell-type specific analysis using CellDMC. CpG loci are aligned on the x-axis according to their genomic coordinates. The y-axis represents the −log10 p values. The dashed black line denotes the Bonferroni-corrected genome-wide significance threshold (pB < 0.05).