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. 2023 Feb 27;13:3333. doi: 10.1038/s41598-023-29280-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Mean of percent pleasantness rating for happy and angry faces. Pleasantness ratings were higher for happy than angry faces and performance did not differ for ONABOTA-Pre and ONABOTA-Active injection. (B) In our a priori anatomical analysis of the amygdalae, we observed pre-post BOLD increase in left amygdala for both happy and angry faces. C) Likewise, we observed a BOLD increase in right fusiform gyrus for happy faces following the ONABOTA injection. Error bars show standard error of the mean. * indicates p < 0.05, # indicates p = 0.06.